Material safety data sheet diisobutylaluminum hydride, 20 wt. Ac201080000, ac20108, ac201084000, ac201088000 synonyms. In the thermal decomposition of the products of the addition of diisobutylaluminum hydride to nitriles rch na1 1c4h92, isobutene is liberated and the corresponding amines rch2h2 are formed after hydrolysis of the residue. Diisobutylaluminum hydride permanent link for this species. Thermal decomposition of products of the addition of. The hazard classification and labelling section shows the hazards of a substance through a standardised system of statements and pictograms, as has been established under clp classification labelling and packaging regulation. It is reducing agent and finds application in the synthesis of apis like orlistat, rosuvastatin, nebivolol, aliskiren, saxagliptin, telaprevir. In the thermal decomposition of the products of the addition of diisobutylaluminum hydride to nitriles rch na1 1c 4 h 9 2, isobutene is liberated and the corresponding amines rch 2 h 2 are formed after hydrolysis of the residue. Use this link for bookmarking this species for future reference. Originally used as a cocatalyst in the zieglernatta polymerization of olefins, diisobutylaluminum hydride dibah is used as a reducing agent in the manufacturer of fine organic chemicals, flavors. Diisobutylaluminum hydride dibah is a pyrophoric liquid supplied undiluted or as a solution in a compatible hydrocarbon solvent. Material safety data sheet diisobutylaluminum hydridedibalh. Mobility will likely be mobile in the environment due to its volatility. Als environmental does not sell chemicals, but offers analytical lab testing to determine the presence of various elements and chemical compounds.
None information in this msds is from available published sources and is believed to be accurate. Heating may cause a fire in contact with water releases flammable gases which may ignite spontaneously may cause fire or explosion. Reduction of substituted amides to aldehydes and amines. Diisobutylaluminum hydride reduces disubstituted amides to the corresponding aldehydes in satisfactory yield. Diisobutyl aluminium hydride is commercially offered as a 25% solution in toluene.
Accidental release measures environmental precautions stop leak if without risk. It has also been used in the synthesis of dialkylaluminum alkoxides from alcohols. This organoaluminium compound was investigated originally as a cocatalyst for the polymerization of alkenes. Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. The clp regulation makes sure that the hazards presented by chemicals are. Diisobutylaluminium hydride substance information echa. We offer this product from chemtura organometallics gmbh, germany. Diisobutylaluminium hydride, 1m solution in hexane. Functional uses pharmaceuticals chemical synthisis. Hydride compounds are used often used as portable sources of hydrogen gas. One reagent lane fair lawn, nj 07410 for information in north america, call. Safety data sheet according to 29cfr19101200 and ghs rev.
To generate bis1,5cyclooctadieneni ckel0 nicod2 in situ, which can catalyze the conjugate addition of ethenyltributyltin to 2propenal to form tertbutyldimethyle1,4pentadienyloxy. Dimethylaluminum hydride is one of numerous organometallic compounds sold by american elements under the trade name ae organometallics for uses requiring nonaqueous solubility such as recent solar energy and water treatment applications. Similar results can sometimes also be achieved with nanoparticles and by thin film deposition. Suppliers list, emailrfq form, molecular structure, weight, formula, iupac, synonyms for diisobutylaluminum hydride cas no. Material safety data sheet diisobutylaluminum hydride. P202 do not handle until all safety precautions have been read and understood. It is useful in organic synthesis for a variety of. Reduction of substituted amides to aldehydes and amines with. Sigmaaldrich material safety data sheet date printed. Instead, slowly add lialh 4 to anhydrous solvent in the reaction flask.
Pyrophorics pyr and selfheating substances and mixtures h250 h251 h252 examples. Derivation classification general description nhexane, a colorless liquid with a slightly disagreeable odor, is the straightchain alkane. Safe method of use for highly hazardous compounds safety guidelines for pyrophoric solids courtesy of department of chemistry, university of auckland researchers shall not use pyrophoric reagents until they have read and fully understood these safe operating procedures. Material safety data sheet hexane 7 section 16 other information msds creation date. Pyrophorics pyr and selfheating substances and mixtures. It is also used as an intermediate in the manufacture of other organometallic compounds, for ethylene oligomerization in. Diisobutylaluminium hydride, 1m solution in hexane, acroseal, acros organics 100ml. Information provided on diisobutylaluminum hydride 1191157 is for reference only and is subject to change. However, reading these procedures does not substitute for handson training. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Procedures for safe use of pyrophoric solids, 22009 page 3 of 4 specific recommendations for working with pyrophoric solid reagents lithium aluminum hydride reacts violently with water and has a significant heat of solvation. No warranty, express or implied, is made and labchem inc.
Cas 1191157 256811 diisobutylaluminum hydride diisobutylaluminum hydride, diisobutylhydroaluminum msds toxicity property. Triethylaluminum teal is primarily used as a cocatalyst in the zieglernatta polymerization of olefins. Used in pdcatalyzed reductive debromination of secondary alkyl bromides. Hexane 110543 80 diisobutylaluminum hydride 1191157 20 4. Diisobutylaluminum hydride is one of numerous organometallic compounds sold by american elements under the trade name ae organometallics for uses requiring nonaqueous solubility such as recent solar energy and water treatment applications. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Gulbrandsen chemicals metal alkyls gulbrandsen technologies. Triethylaluminum teal is a pyrophoric liquid supplied undiluted or as a solution in a compatible hydrocarbon solvent. Diisobutylaluminum hydride readily reduces di and mono. Prevent entry into sewers, water courses, basements or confined areas. Diisobutylaluminum hydride readily reduces di and monosubstituted amides to the corresponding amines. Bioaccumulation accumulationno information available.
Diisobutylaluminium hydride dibalh, dibal, dibalh or dibah. Sigmaaldrich 9386 page 1 of 7 sigmaaldrich material safety data sheet version 4. Diisobutylaluminium hydride, 1m solution in hexane, acroseal. Diisobutylaluminum hydride not listed as a carcinogen by acgih, iarc, ntp, or ca prop 65. Reducing agentdiisobutylaluminum hydride, 1m solution in hexane is used in pdcatalyzed reductive debromination of secondary alkyl bromides, odebenzylation and ring opening of perbenzylated furanosides. A ester to aldehyde b carboxylic acid to ester c 2 alcohol to ketone d aldehyde to carboxylic acid e ester to ketone answer. It is involved in the in situ generation of hzrcp 2 cl by reacting with zrcp 2 cl 2.
Firstaid measures general advice show this safety data sheet to the doctor in attendance. Predicted data is generated using the us environmental protection agencys episuite. Diisobutylaluminium hydride solution heptane suppliers. Diisobutylaluminum hydride 1, more commonly known as dibal or dibalh, is a reducing agent dibal can be used to reduce many a functional group, but it is most commonly used to reduce carboxylic acid esters to aldehydes, which can not be done using lithium aluminumhydride, the traditional reducing agent used to reduce carbonyl compounds. Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910.
Diisobutylaluminum hydride solution 1m in toluene has been used for the reduction of aziridine esters to the corresponding aldehydes. Application diisobutylaluminum hydride solution 1m in thf is a powerful reducing agent. Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, gmp products, impurities and metabolites, apis for veterinary, natural compounds, adcs, stem cell molecule and chiral compounds. See actual entry in rtecs for complete information. Diisobutylaluminum hydride dibalh is a common reducing agent to reduce aldehydes, ketones, esters, acids and acid chlorides to the corresponding alcohols.
If unconscious place in recovery position and seek medical advice. Safety data sheet northwest missouri state university. Diisobutylaluminum hydride 1, more commonly known as dibal or dibalh, is a reducing agent dibal can be used to reduce many a functional group, but it is most commonly used to reduce carboxylic acid esters to aldehydes, which can not be done using lithium aluminumhydride, the traditional reducing agent used to reduce carbonyl compounds eg. Safe method of use for highly hazardous compounds safety. Sigmaaldrich 3050 spruce street saint louis mo 63103 usa. The toxicological properties have not been fully investigated. Diisobutylaluminum hydride reducing agent is commonly used for the reduction of an ester to aldehyde. P210 keep away from heatsparksopen flameshot surfaces. Prepared by safety and environmental affairs msds issue date. Acroseal glass bottle packed in tin can diisobutylaluminium hydride, 1m. The hazard classification and labelling section shows the hazards of a substance based on the standardised system of statements and pictograms established under the clp classification labelling and packaging regulation. The clp regulation makes sure that the hazards presented by chemicals are clearly communicated to. Many pyrophorics are supplied as solutions in flammable. Dcm, thf, hexanes, heptane, toluene, and cyclohexane.
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